The National Toxicology Program has released the Peer Review Report with recommendations from scientists and the medical community collected at a meeting held March 26–28, 2018 at the National Institute of Environmental Health Sciences Research in Triangle Park, NC.
The assembled researchers voted to increase “the level of confidence for seven tumor types.” The malignant schwannomas found in male rats were deemed “clear evidence” of cancer. The malignant gliomas in the brain, and pheochromocytoma in the adrenal medulla (GSM only) of male rats were deemed “some evidence” of cancer. Increased right ventricular cardiomyopathy in the heart was found in the exposed groups. In addition, several other tumors were increased in the exposed groups and DNA damage was found in various organs.
On June 20, 2018, Drs. Chad Blystone and Michael Wyde, NIEHS/DNTP made presentations to the NTP’s Board of Scientific Counselors Meeting that summarize the study findings.
“At the end of the two-year studies,” the report stated “A number of neoplastic lesions were also observed that were considered equivocal findings that may have been related to RFR exposure in male (brain (granular cell tumors), pituitary gland, prostate, liver, adrenal gland, and pancreas) and female rats (heart, brain, and adrenal gland).”
“In the rat studies, exposures were initiated in utero and consistently resulted in exposure concentration-related decreases in pup body weight and body weight gains during the perinatal period. In general, decreased pup survival was observed at the higher levels of RFR tested. Increased DNA damage in cells of the hippocampus and frontal cortex was observed in RFR-exposed male mice from the CDMA study.”
“The primary finding observed in mice in these studies was increased DNA damage in cells of the frontal cortex of RFR-exposed male mice (both GSM and CDMA). This finding was not associated with any change in brain tumors in the two-year studies; however, elevated incidences of neoplastic lesions were observed in male (skin and lung) and female mice (malignant lymphomas).”
July 6, 2018